许国旺研究员

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许国旺研究员

中国科学院大连化学物理研究所

国家色谱中心

高分辨分离分析及代谢组学组(1808组)

代谢组学研究分析中心

电话: 0411-84379530

传真: 0411-84379559

Email:xugw@dicp.ac.cn

地址:大连市中山路457号

邮编: 116023

Prof. Guowang Xu

Director for Metabonomics Research Center

National Chromatographic R. & A. Center

Dalian Institute of Chemical Physics, Chinese Academy of Sciences

Dalian 116023, China

Tel: 86-411-84379530.

Fax:86-411-84379559

Email: xugw@dicp.ac.cn

Homepage :http://www.402.dicp.ac.cn


许国旺: 1991年在中国科学院大连化物所获理学博士学位,并留所在国家色谱研究分析中心工作。1995.10-1997.9获得马普(Max-Planck-Institut)研究基金在德国Tuebingen大学医学院工作。1997年9月底回国在大连化物所继续担任题目组长,97年11月提升为研究员。99年5月被聘为博士生导师。2004年获国家自然科学基金委杰出青年基金资助,2005年起担任代谢组学研究中心主任,2008年、2017年起分别担任中国科学院分离分析化学重点实验室副主任和主任,2016年起担任大连化物所生物技术部常务副主任。现为中国化学会色谱专业委员会主任、中国抗癌协会肿瘤代谢委员会副主任、中国生物工程学会系统生物医学专业委员会副主任、中国化学会理事、中国质谱学会常务理事。2007-2014年曾任J. Chromatogr. B的editor,现正在担任TrAC的特约编辑和Anal. Chem., Anal. Chim. Acta,J. Proteome Res., Metabolites,Metabolomics,Anal. Bioanal. Chem.,J. Chromatogr. B,J. Sep. Sci., JOAT, Bull Korean Chem. Soc.等10多个杂志编委。国际高效液相色谱会议(HPLC)科学委员会常委,第30届国际毛细管色谱会议和第33、37届国际高效液相色谱会议副主席。他也是多届国际毛细管色谱会议(ISCC)的科学委员会委员和国际代谢组学会议的组织者和科学委员会成员。

至今为止,已发表SCI文章490多篇,包括PNAS, Nature Protocols, Nature Communications, Hepatology, Clin. Chem., Cancer Res., Advanced Science, Diabetes Care, Anal. Chem., TrAC, J. Chromatogr. A, J. Proteome Res. and Nature Methods等国际著名杂志。H-指数: 68(Web of Science)、85 (Google)。申请发明专利超百件(其中70多项曾获授权)。一项成果获国家科技进步二等奖(第五名),一项获辽宁省科技发明二等奖(第一名),一项成果获中国分析测试协会科学技术成果特等奖(第一名)。

许国旺研究员一直从事色谱及其联用技术的基础理论及应用研究。根据样品对象的复杂性,在方法学上,走过了从经典一维色谱到中心切割多维色谱、再到全二维色谱的研究过程,逐渐形成了以“多维色谱+联用技术+化学信息学”的科研特色;在研究对象上,从石化、环保领域逐渐实现了向生命科学(药物、代谢组学、生物催化)领域的转化。从1996年开始开展“健康和代谢的关系”研究,并逐步进入代谢组学领域,将研究方向集中到代谢组学的技术平台和其在重大疾病的生物标志物发现、中药疗效毒性和作用机理研究、食品安全和暴露组学研究等。许国旺是我国最早进行代谢组学研究的学者之一。

主要研究方向:复杂样品分离分析方法的创新性研究;代谢组学、暴露组学分析技术平台及其在疾病、中药、植物表型、食品安全等方面应用的研究。


代表性文章:

1. Zhen Ning#, Xin Guo#, Xiaolong Liu#, Chang Lu#, Aman Wang, Xiaolin Wang, Wen Wang, Huan Chen, Wangshu Qin, Xinyu Liu, Lina Zhou, Chi Ma, Jian Du, Zhikun Lin, Haifeng Luo, Wuxiyar Otkur, Huan Qi, Di Chen, Tian Xia, Jiwei Liu, Guang Tan*, Guowang Xu*, Hai-long Piao* (2022) USP22-dependent accumulation of lipidomes drives hepatocellular carcinoma progression by stabilizing PPARγ, Nat. Commun., 13(1): 2187. doi: 10.1038/s41467-022-29846-9.  

2. Lei You, Fujian Zheng, Chang Su, Limei Wang, Xiang Li, Qianqian Chen, Jing Kou, Xiaolin Wang, Yanfeng Wang, Yuting Wang, Surong Mei, Bing Zhang*, Xinyu Liu*, Guowang Xu* (2022) Metabolome-wide association study of serum exogenous chemical residues in a cohort with 5 major chronic diseases, Environment International, 158, 106919.

3. Wenying Liang, Fujian Zheng, Tiantian Chen, Xiuqiong Zhang, Yueyi Xia, Zaifang Li, Xin Lu, Chunxia Zhao*, Guowang Xu* (2022) Nontargeted Screening Method for Veterinary Drugs and Their Metabolites Based on Fragmentation Characteristics from Ultrahigh-Performance Liquid Chromatography–High-Resolution Mass Spectrometry, Food Chem. 369, 130928.

4. Saleh Alseekh*, Asaph Aharoni, Yariv Brotman, Kévin Contrepois, John D'Auria, Jan Ewald, Jennifer C Ewald , Paul D Fraser, Patrick Giavalisco, Robert D Hall , Matthias Heinemann , Hannes Link, Jie Luo, Steffen Neumann , Jens Nielsen, Leonardo Perez de Souza, Kazuki Saito, Uwe Sauer, Frank C Schroeder, Stefan Schuster, Gary Siuzdak, Aleksandra Skirycz, Lloyd W Sumner, Michael P Snyder, Huiru Tang , Takayuki Tohge, Yulan Wang, Weiwei Wen, Si Wu, Guowang Xu, Nicola Zamboni, Alisdair R. Fernie* (2021) Mass spectrometry-based metabolomics: a guide for annotation, quantification and best reporting practices, Nature Methods, 18(7):747-756.

5. Tianrun Xu, Hang Li, Disheng Feng, Xianzhe Shi, Chunxiu Hu*, Guowang Xu* (2021) Lipid profiling of 20 mammalian cells by capillary microsampling combined with high-resolution spectral stitching nanoelectrospray ionization direct-infusion mass spectrometry, Anal. Chem. 93, 10031−10038.

6. Mengmeng Chang, Qingqing Wang, Xinyu Liu*, Xianzhe Shi*, Guowang Xu* (2021) Facile Synthesis of Antibody-Coupled Polydopamine Coated Magnetic Graphene Oxide Composites for Efficient Immunopurification and Metabolomics Analysis of Mitochondria, Anal. Chem., 93, 11099−11107.

7. Fujian Zheng, Xinjie Zhao, Zhongda Zeng, Lichao Wang, Wangjie Lv, Qingqing Wang, Guowang Xu* (2020) Development of plasma pseudotargeted metabolomics method based on ultra-high performance liquid chromatography-mass spectrometry, Nature Protocols, 15(8):2519-2537.

8. Di Yu, Yang Liu, Yiqiang Zhou, Guowang Xu*, Chunzhang Yang* (2020) Triptolide suppresses IDH1-mutated malignancy via Nrf2-driven glutathione metabolism, Proc Natl Acad Sci U S A, 117(18):9964-9972.

9. Zujiang Yu,*, Jingjing Li, Ranran Sun, Yang Zhou, Qi Zhang, Qiongye Wang, Guangying Cui, Juan Li, Zhenfeng Duan, Xiaochao Ma, Yuming Xu, Zhichao Wang, Peiyuan Yin, Hailong Piao, Jun Lv, Xiaorui Liu, Yanfang Wang, Ming Fang, Zhengping Zhuang*, Guowang Xu*, Quancheng Kan* (2020) Switching from Fatty Acid Oxidation to Glycolysis Improves the Outcome of Acute-On-Chronic Liver Failure, Advanced Science, 7, 1902996.

10. Qiuhui Xuan#, Yang Ouyang#, Yanfeng Wang#, Liang Wu#, Huating Li, Yuanyuan Luo, Xinjie Zhao, Disheng Feng, Wangshu Qin, Chunxiu Hu, Lina Zhou, Xinyu Liu, Haidong Zou, Chun Cai, Jiarui Wu*, Weiping Jia*, Guowang Xu* (2020) Applications of Multi-Platform Metabolomics in Studying Metabolic Pathway Dysregulation and Discovering Novel Serum Metabolite Biomarkers to Identify Diabetic Retinopathy Subjects from Patients with Diabetes, Advanced Science, 2020, 7, 2001714.

11. Wangjie Lv, Lichao Wang, Qiuhui Xuan, Xinjie Zhao, Xinyu Liu, Xianzhe Shi *, Guowang Xu * (2020) Pseudotargeted Method based on Parallel Column Two-Dimensional Liquid Chromatography-Mass Spectrometry for Broad Coverage of Metabolome and Lipidome, Anal. Chem., 92(8):6043-6050.

12. Yifei Zhang, Yanyun Gu, Huahui Ren, Shujie Wang, Huanzi Zhong, Xinjie Zhao,Jing Ma, Xuejiang Gu, Yaoming Xue, Shan Huang, Jialin Yang, Li Chen, Gang Chen, Shen Qu, Jun Liang, Li Qin, Qin Huang, Yongde Peng, Qi Li, Xiaolin Wang, Kong Ping, Guixue Hou, Mengyu Gao, Zhun Shi, Xuelin Li, Yixuan Qiu, Yuanqiang Zou, Huanming Yang, Jian Wang, Guowang Xu, Shenghan Lai, Junhua Li*, Guang Ning*,Weiqing Wang* (2020) Gut microbiome-related effects of berberine and probiotics on type 2 diabetes (the PREMOTE study), Nature Communications, 11(1): 5015.

13. Wangjie Lv #, Xianzhe Shi #, Shuangyuan Wang, Guowang Xu *(2019) Multidimensional liquid chromatography-mass spectrometry for metabolomics and lipidomics, TrAC-Trend Anal. Chem., 120, 115302 .

14. Xinyu Liu#, Lina Zhou#, Xianzhe Shi, Guowang Xu* (2019) New advances in analytical methods for mass spectrometry-based large-scale metabolomics study, TrAC-Trend Anal. Chem., 121, 115665.

15. Ping Luo#, Peiyuan Yin#, Rui Hua#, Yexiong Tan, Zaifang Li#, Gaokun Qiu, Zhenyu Yin, Xingwang Xie, Xiaomei Wang, Wenbin Chen, Lina Zhou, Xiaolin Wang, Yanli Li, Hongsong Chen, Ling Gao, Xin Lu, Tangchun Wu*, Hongyang Wang*, Junqi Niu*, Guowang Xu* (2018) A large-scale, multi-center serum metabolite biomarkers identification study for the early detection of hepatocellular carcinoma, Hepatology, 67:662-675.

16. Ling Tang, Jun Zeng, Pengyu Geng, Chengnan Fang, Yang Wang, Mingju Sun, Changsong Wang, Jiao Wang, Peiyuan Yin, Chunxiu Hu, Lei Guo, Jane J. Yu, Peng Gao, Enyou Li, Zhengping Zhuang, Guowang Xu* ,Yang Liu* (2018) Global metabolic profiling identifies a pivotal role of proline and hydroxyproline metabolism in supporting hypoxic response in hepatocellular carcinoma, Clin. Cancer Res., 24(2):474-485.

17. Di Yu, Lina Zhou, Qiuhui Xuan, Lichao Wang, Xinjie Zhao, Xin Lu, Guowang Xu* (2018) Strategy for Comprehensive Identification of Acylcarnitines Based on Liquid Chromatography—High-Resolution Mass Spectrometry, Anal. Chem., 90(9):5712-5718.

18. Xinyu Liu, Miriam Hoene, Peiyuan Yin, Louise Fritsche, Peter Plomgaard, Jakob S. Hansen, Christos T. Nakas, Andreas M. Niess, Jens Hudemann, Michael Haap, Maimuna Mendy, Cora Weigert, Xiaolin Wang, Andreas Fritsche, Andreas Peter, Hans-Ulrich Häring, Guowang Xu*, Rainer Lehmann*(2018) Quality Control of Serum and Plasma by Quantification of (4E,14Z)-Sphingadienine-C18-1-Phosphate Uncovers Common Preanalytical Errors During Handling of Whole Blood, Clin. Chem., 64(5): 810–819.

19. Shuangyuan Wang#, Zhichao Wang#, Lina Zhou, Xianzhe Shi*, Guowang Xu* (2017) Comprehensive analysis of short-, medium- and long-chain acyl-coenzyme As by on-line two dimensional liquid chromatography-mass spectrometry, Anal. Chem., 89(23):12902-12908.

20. Rui Wu, Zeming Wu, Xianhui Wang, Pengcheng Yang, Dan Yu, Chunxia Zhao, Guowang Xu*, Le Kang* (2012) Metabolomic analysis reveals that carnitines are key regulatory metabolites in phase transition of the locusts, Proc Natl Acad Sci U S A, 109(9):3259-63.


Laboratory of High Resolution Separation/Analysis and Metabonomics   Dalian Institute of Chemical Physics, Chinese Academy of Sciences. All Rights Reserved.
中国科学院大连化学物理研究所  生物分子高分辨分离分析及代谢组学研究组(1808组)
地址: 大连市中山路457号, 邮编: 116023 电话: 0411-84379531; 传真: 0411-84379559     Email: g1808@dicp.ac.cn