1

USP22 regulates lipidome accumulation by stabilizing PPARγ in hepatocellular carcinoma

Nature Communications, 2022,13, 2187

Zhen Ning, Xin Guo, Xiaolong Liu, Chang Lu, Aman Wang, Xiaolin Wang, Wen Wang, Huan Chen, Wangshu Qin, Xinyu Liu, Lina Zhou, Chi Ma, Jian Du, Zhikun Lin, Haifeng Luo, Wuxiyar Otkur, Huan Qi, Di Chen, Tian Xia, Jiwei Liu, Guang Tan*, Guowang Xu*, Hai-long Piao*

Guang Tan*, Guowang Xu*, Hai-long Piao*

17.694

2

Amino acids, microbiota-related metabolites, and the risk of incident diabetes among normoglycemic Chinese adults: Findings from the 4C study.

Cell reports. Medicine, 2022, 3, 100727(1-16)

Shuangyuan Wang, Mian Li, Hong Lin, Guixia Wang, Yu Xu, Xinjie Zhao, Chunyan Hu, Yi Zhang,Ruizhi Zheng,Ruying Hu,Lixin Shi, Rui Du, Qing Su, Jiqiu Wang, Yuhong Chen, Xuefeng Yu, Li Yan, Tiange Wang, Zhiyun Zhao, Ruixin Liu, Xiaolin Wang, Qi Li, Guijun Qin,Qin Wan, Gang Chen,Min Xu,Meng Dai, Di Zhang, Xulei Tang, Zhengnan Gao, Feixia Shen, Zuojie Luo, Yingfen Qin, Li Chen, Yanan Huo, Qiang Li, Zhen Ye, Yinfei Zhang,Chao Liu,Youmin Wang, Shengli Wu,Tao Yang, Huacong Deng, Jiajun Zhao, Shenghan Lai, Yiming Mu, Lulu Chen, Donghui Li, Guowang Xu, Guang Ning*, Weiqing Wang*, Yufang Bi*, Jieli Lu*, for the 4C Study Group

Guang Ning*,Weiqing Wang*, Yufang Bi*, Jieli Lu*

16.988

3

Recent advances and typical applications in mass spectrometry-based technologies for single-cell metabolite analysis

Trac-Trends in Analytical Chemistry, 2022, 157, 116763(1-13)

Tianrun Xu#, Disheng Feng#, Hang Li, Xuesen Hu, Ting Wang, Chunxiu Hu**, Xianzhe Shi***, Guowang Xu*

Chunxiu Hu**, Xianzhe Shi***, Guowang Xu*

14.908

4

Metabolome-wide association study of serum exogenous chemical residues in a cohort with 5 major chronic diseases

Environment International, 2022, 158, 106919(1-13)

Lei You, Fujian Zheng, Chang Su, Limei Wang, Xiang Li, Qianqian Chen, Jing Kou, Xiaolin Wang, Yanfeng Wang, Yuting Wang, Surong Mei, Bing Zhang*, Xinyu Liu*, Guowang Xu*

Bing Zhang*, Xinyu Liu*, Guowang Xu*

13.352

5

AKR1C3-dependent lipid droplet formation confers hepatocellular carcinoma cell adaptability to targeted therapy

Theranostics, 2022, 12, 7681-7698

Changing Wu#, Chaoliu Dai#, Xinyu Li#, Mingju Sun, Hongwei Chu, Qiuhui Xuan, Yalei Yin, Chengnan Fang, Fan Yang, Zhonghao Jiang, Qing Lv, Keqing He, Yiying Qu, Baofeng Zhao, Ke Cai, Shuijun Zhang, Ran Sun, Guowang Xu, Lihua Zhang, Siyu Sun*, Yang Liu*

Siyu Sun*, Yang Liu*

11.6

6

Metabolome-Wide Association Study of Multiple Plasma Metals with Serum Metabolomic Profie among Middle-to-Older-Aged Chinese Adults

Environmental Science & Technology, 2022, 56, 16001-16011

Yuhui Lin, Yu Yuan, Yang Ouyang, Hao Wang, Yang Xiao, Xinjie Zhao, Handong Yang, Xiulou Li, Huan Guo, Meian He, Xiaomin Zhang, Guowang Xu, Gaokun Qiu*, Tangchun Wu*

Gaokun Qiu*, Tangchun Wu*

11.357

7

Metabolomics insights into the prenatal exposure effects of polybrominated diphenyl ethers on neonatal birth outcomes

Science of the Total Environment, 2022, 836, 155601(1-11)

Yanfeng Wang#, Qihua Wang#, Lina Zhou#, Zhijun Zeng#, Chunxia Zhao, Lei You, Xin Lu, Xinyu Liu, Runzeng Ouyang, Yuting Wang, Xijin Xu, Xiwen Tian, Yufeng Guo, Xia Huo*, Guowang Xu*

Xia Huo*, Guowang Xu*

10.754

8

Accumulative levels, temporal and spatial distribution of common chemical pollutants in the blood of Chinese adults

Environmental Pollution, 2022, 311, 119980(1-14)

Jing Kou, Xiang Li, Mingye Zhang, Limei Wang, Liqin Hu, Xinyu Liu, Surong Mei*, Guowang Xu

Surong Mei*

9.988

9

Combined berberine and probiotic treatment as an effective regimen for improving postprandial hyperlipidemia in type 2 diabetes patients: a double blinded placebo controlled randomized study

Gut Microbes, 2022, 14, e2003176(1-21)

Shujie Wang, Huahui Ren,Huanzi Zhong, Xinjie Zhao, Changkun Li, Jing Ma, Xuejiang Gu, Yaoming Xue, Shan Huang, Jialin Yang, Li Chen, Gang Chen, Shen Qu, Jun Liang, Li Qin, Qin Huang, Yongde Peng, Qi Li, Xiaolin Wang, Yuanqiang Zou, Zhun Shi, Xuelin Li, Tingting Li, Huanming Yang, Shenghan Lai, Guowang Xu, Junhua Li*, Yifei Zhang*, Yanyun Gu*, Weiqing Wang*

Junhua Li*, Yifei Zhang*, Yanyun Gu*, Weiqing Wang*

9.434

10

Nontargeted screening method for veterinary drugs and their metabolites based on fragmentation characteristics from ultrahigh-performance liquid chromatography-high-resolution mass spectrometry

Food Chemistry, 2022, 369, 130928(1-9)

Wenying Liang, Fujian Zheng, Tiantian Chen, Xiuqiong Zhang, Yueyi Xia, Zaifang Li, Xin Lu, Chunxia Zhao*, Guowang Xu*

Chunxia Zhao*, Guowang Xu*

9.231

11

MetEx: A Targeted Extraction Strategy for Improving the Coverage and Accuracy of Metabolite Annotation in Liquid Chromatography-High-Resolution Mass Spectrometry Data

Analytical Chemistry, 2022, 94, 8561-8569

Fujian Zheng, Lei You, Wangshu Qin, Runzeng Ouyang, Wangjie Lv, Lei Guo, Xin Lu, Enyou Li, Xinjie Zhao*, Guowang Xu*

Xinjie Zhao*, Guowang Xu*

8.008

12

Novel Method for Comprehensive Annotation of Plant Glycosides Based on Untargeted LC-HRMS/MS Metabolomics

Analytical Chemistry, 2022, 94, 16604-16613

Xiuqiong Zhang, Fujian Zheng, Chunxia Zhao, Zaifang Li, Chao Li, Yueyi Xia, Sijia Zheng, Xinxin Wang, Xiaoshan Sun, Xinjie Zhao, Xiaohui Lin, Xin Lu*, Guowang Xu*

Xin Lu*, Guowang Xu*

8.008

13

Medium-chain triglyceride production in Nannochloropsis via a fatty acid chain length iscriminating mechanism

Plant Physiology, 2022, 190, 1658-1672

Yi Xin*, Qintao Wang, Chen Shen, Chunxiu Hu*, Xianzhe Shi, Nana Lv, Xuefeng Du, Guowang Xu, Jian Xu*

Yi Xin*, Chunxiu Hu*, Jian Xu *

8.005

14

Metabolic Reprogramming and Its Relationship to Survival in Hepatocellular Carcinoma

Cells, 2022, 11, 1066(1-15)

Qingqing Wang, Yexiong Tan, Tianyi Jiang, Xiaolin Wang, Qi Li, Yanli Li, Liwei Dong*, Xinyu Liu*, Guowang Xu*

Liwei Dong*, Xinyu Liu*, Guowang Xu*

7.666

15

Interplay between dietary intake, gut microbiota, and metabolic profile in obese adolescents: Sex-dependent differential patterns

Clinical Nutrition, 2022, 41, 2706-2719

Yang Liu, Lei Chen, Lei Liu, Shan-Shan Zhao, Jun-Qiao You, Xinjie Zhao***, Hui-Xin Liu**, Guowang Xu, De-Liang Wen*

Xinjie Zhao***, Hui-Xin Liu**,De-Liang Wen*

7.643

16

Comprehensive metabolite quantitative assay based on alternate metabolomics and lipidomics analyses

Analytica Chimica Acta, 2022, 1215, 339979(1-8)

Wangjie Lv, Zhongda Zeng, Yuqing Zhang, Qingqing Wang, Lichao Wang, Zhaoxuan Zhang, Xianzhe Shi, Xinjie Zhao**, Guowang Xu*

Xinjie Zhao**, Guowang Xu*

6.911

17

High-throughput single cell metabolomics and cellular heterogeneity exploration by inertial microfluidics coupled with pulsed electric field-induced electrospray ionization-high resolution mass spectrometry

Analytica Chimica Acta, 2022, 1221, 340116(1-10)

Disheng Feng, Hang Li, Tianrun Xu, Fujian Zheng, Chunxiu Hu, Xianzhe Shi**, Guowang Xu*

Xianzhe Shi**, Guowang Xu*

6.911

18

Metabolic Reprogramming and Risk Stratification of Hepatocellular Carcinoma Studied by Using Gas Chromatography-Mass Spectrometry-Based Metabolomics

Cancers,2022, 14, 231(1-17)

Chengnan Fang, Hui Wang, Zhikun Lin, Xinyu Liu, Liwei Dong, Tianyi Jiang, Yexiong Tan, Zhen Ning Yaorui Ye, Guang Tan*, Guowang Xu*

Guang Tan*, Guowang Xu*

6.575

19

In-depth characterization of nitrogen heterocycles of petroleum by liquid chromatography-energy-resolved high resolution tandem mass spectrometry

Talanta, 2022, 249, 123654(1-9)

Yueyi Xia, Xiaoshan Sun, Xinjie Zhao, Disheng Feng, Xiaoxiao Wang, Zaifang Li, Chenfei Ma, Hua Zhang, Chunxia Zhao, Xiaohui Lin, Xin Lu*, Guowang Xu**

Xin Lu*, Guowang Xu**

6.556

20

In-depth profiling of carboxyl compounds in Chinese Baijiu based on chemical derivatization and ultrahigh-performance liquid chromatography coupled to high-resolution mass spectrometry

Food Chemistry-X, 2022, 15, 100440(1-7)

Xiaoyu Xie, Xin Lu, Xiuqiong Zhang, Fujian Zheng, Di Yu, Chao Li, Sijia Zheng, Bo Chen, Xinyu Liu, Ming Ma*, Guowang Xu*

Ming Ma*, Guowang Xu*

6.443

21

Identification and Validation of TRIM25 as a Glucose Metabolism Regulator in Prostate Cancer

International Journal of Molecular Sciences, 2022, 23, 9325(1-15)

Chao Li#, Peng Dou#, Xin Lu, Pengwei Guan, Zhikun Lin, Yanyan Zhou, Xin Lu*, Xiaohui Li, Guowang Xu*

Xin Lu*, Guowang Xu*

6.208

22

Serum Metabonomics Reveals Risk Factors in Different Periods of Cerebral Infarction in Humans

Frontiers in Molecular Biosciences, 2022, 8, 784288(1-20)

Guoyou Chen#, Li Guo#, Xinjie Zhao#, Yachao Ren, Hongyang Chen, Jincheng Liu, Jiaqi Jiang, Peijia Liu, Xiaoying Liu, Bo Hu, Na Wang, Haisheng Peng*, Guowang Xu*

Haisheng Peng*, Guowang Xu*

6.113

23

Genetic manipulation of the interconversion between diacylglycerols and triacylglycerols in Rhodosporidium toruloides

Frontiers in Bioengineering and Biotechnology, 2022, 10, 1034972(1-13)

Yue Zhang, Sufang Zhang, Yadong Chu, Qi Zhang, Renhui Zhou, Di Yu, Shuang Wang, Liting Lyu, Guowang Xu, Zongbao Kent Zhao*

Zongbao Kent Zhao*

6.064

24

Diagnostic Performance of Sex-Specific Modified Metabolite Patterns in Urine for Screening of Prediabetes

Frontiers in Endocrinology, 2022, 13, 935016(1-12)

Zaifang Li#, Yanhui Zhang#, Miriam Hoene, Louise Fritsche, Sijia Zheng, Andreas Birkenfeld, Andreas Fritsche, Andreas Peter, Xinyu Liu, Xinjie Zhao, Lina Zhou, Ping Luo, Cora Weigert, Xiaohui Lin*, Guowang Xu*, Rainer Lehmann*

Xiaohui Lin*, Guowang Xu*, Rainer Lehmann*

6.055

25

Serum lipidomics profiles reveal potential lipid markers for prediabetes and type 2 diabetes in patients from multiple communities

Frontiers in Endocrinology, 2022, 13, 966823(1-13)

Qiuhui Xuan, Chunxiu Hu, Yinan Zhang, Qingqing Wang, Xinjie Zhao, Xinyu Liu, Congrong Wang*, Weiping Jia*, Guowang Xu*

Congrong Wang*, Weiping Jia*, Guowang Xu*

6.055

26

Plasma Metabolomic and Lipidomic Profiling of Metabolic Dysfunction-Associated Fatty Liver Disease in Humans Using an Untargeted Multiplatform Approach

Metabolites, 2022, 12, 1081(1-18)

Xiangping Lin#, Xinyu Liu, Mohamed N. Triba, Nadia Bouchemal, Zhicheng Liu, Douglas I. Walker, Tony Palama, Laurence Le Moyec, Marianne Ziol, Nada Helmy,Corinne Vons, Guowang Xu*, Carina Prip-Buus*, Philippe Savarin*

Guowang Xu*, Carina Prip-Buus*, Philippe Savarin*

5.581

27

Effect of Breastmilk Microbiota and Sialylated Oligosaccharides on the Colonization of Infant Gut Microbial Community and Fecal Metabolome

Metabolites, 2022, 12, 1136(1-15)

Juan Ding#, Runze Ouyang#, Sijia Zheng#, Yanfeng Wang, Yan Huang, Xiao Ma, Yuxin Zou, Rong Chen, Zhihong Zhuo, Zhen Li, Qi Xin, Lina Zhou, Surong Mei, Jingyu Yan, Xin Lu, Zhigang Ren*, Xinyu Liu*, Guowang Xu

Zhigang Ren*, Xinyu Liu*

5.581

28

Glycolytic potential enhanced by blockade of pyruvate influx into mitochondria sensitizes prostate cancer to detection and radiotherapy

Cancer Biology & Medicine, 2022, 1-19

Huan Xu#, Junyi Chen#, Zhi Cao, Xi Chen, Caihong Huang, Jin Ji, Yalong Xu, Junfeng Jiang, Yue Wang, Guowang Xu, Lina Zhou, Jingyi He, Xuedong Wei, Jason Boyang Wu, Zhong Wang, Shancheng Ren*, Fubo Wang*

Shancheng Ren*, Fubo Wang*

5.347

29

A data processing pipeline for petroleomics based on liquid chromatography-high resolution mass spectrometry

Journal of Chromatography. A, 2022, 1673, 463194(1-9)

Yueyi Xia, Xiaoxiao Wang, Chenfei Ma, Xinxin Wang, Chunxia Zhao, Xinjie Zhao, Zhanquan Zhang, Yinglong Yue, Xiaohui Lin∗, Xin Lu∗∗, Guowang Xu∗∗

Xiaohui Lin∗, Xin Lu∗∗,Guowang Xu∗∗

4.601

30

Data analysis methods for defining biomarkers from omics data

Analytical and Bioanalytical Chemistry, 2022, 414, 235-250

Chao Li, Zhenbo Gao, Benzhe Su, Guowang Xu, Xiaohui Lin*

Xiaohui Lin

4.478

31

Effect of roxadustat on serum metabolome and lipidome in patients with end-stage renal disease and erythropoiesis-stimulating agent resistance

Annals of Translational Medicine, 2022, 10, 1069(1-11)

Lichao Wang#, Yulin Wu#, Yongjiang Li, Lianlian You, Xinyu Liu, Zhihong Wang, Jia Xiao, Shuang Zhang, Tianrun Xu, Xiaolin Wang, Qi Li, Chunxiu Hu*, Guowang Xu*, Shuxin Liu*

Chunxiu Hu*, Guowang Xu*, Shuxin Liu*

3.616

32

Nontargeted screening of veterinary drugs and their metabolites in milk based on mass defect filtering using liquid chromatography-high-resolution mass spectrometry

Electrophoresis, 2022, 43, 1822-1831

Tiantian Chen, Wenying Liang, Xiuqiong Zhang, Xin Lu, Chunxia Zhao*, Guowang Xu*

Chunxia Zhao*, Guowang Xu*

3.595

33

Defect in Ser312 phosphorylation of Tp53 dysregulates lipid metabolism for fatty accumulation and fatty liver susceptibility: Revealed by lipidomics

Journal of Chromatography B-Analytical Technologies in The Biomedical and Life Sciences, 2022, 1211, 123491(1-11)

Min He*, Elizabeth A. Slee, Mengmeng Sun, Chunxiu Hu, Wen-Te Chang, Guowang Xu, Xin Lu, Mei Wan*

Min He*, Mei Wan*

3.318

34

FluxomicsExplorer: Differential visual analysis of Flux Sampling based on Metabolomics

Computers & Graphics-Uk, 2022, 108, 11-21

Constantin Holzapfel, Miriam Hoene, Xinjie Zhao, Chunxiu Hu, Cora Weigert, Andreas Niess f, Guowang Xu, Rainer Lehmann, Andreas Dräger, Michael Krone∗

Michael Krone∗

1.821

35

2.03 - Early Life Microbiota-Impact of Delivery Mode and Infant Feeding

Comprehensive Gut Microbiota

Runze Ouyang, Katri Korpela, Xinyu Liu, Guowang Xu, Willem M de Vos, Petia Kovatcheva-Datcharye*

Petia Kovatcheva-Datcharye*

专著章节

36

基于修饰组和探针分子的重要途径代谢物筛选和注释新方法

色谱, 2022, 40, 788 - 796

李在芳#,郑福建#,夏悦怡,张秀琼,王鑫欣,赵春霞,赵欣捷,路鑫*,许国旺

路鑫*

1.823

37

基于质谱数据的计算代谢组学方法学研究进展

中国科学：化学, 2022, 52, 1580-1591

杨军,刘心昱*,许国旺

刘心昱*

0.616