许国旺研究员Prof.Guowang Xu

作者:时间:2019-07-24点击数:

 

 

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许国旺研究员

Prof. Dr. Guowang Xu

中国科学院大连化学物理研究所

国家色谱中心

高分辨分离分析及代谢组学组(1808组)

代谢组学研究分析中心

电话: 0411-84379530

传真: 0411-84379559

Email:xugw@dicp.ac.cn

地址:大连市中山路457号

邮编: 116023

 

Director for Metabonomics Research Center

National Chromatographic R. & A. Center

Dalian Institute of Chemical Physics, Chinese Academy of Sciences

Dalian 116023, China

Tel: 86-411-84379530.

Fax:86-411-84379559

Email: xugw@dicp.ac.cn

Homepage : http://www.402.dicp.ac.cn 


许国旺: 1991年在中国科学院大连化物所获理学博士学位,并留所在国家色谱研究分析中心工作。1995.10-1997.9获得马普(Max-Planck-Institut)研究基金在德国Tuebingen大学医学院工作。19979月底回国在大连化物所继续担任题目组长,199711月提升为研究员。995月被聘为博士生导师。2004年获国家自然科学基金委杰出青年基金资助,2005年起担任代谢组学研究中心主任,2008年、2017年起分别担任中国科学院分离分析化学重点实验室副主任和主任,2016年起担任大连化物所生物技术部常务副主任。现为中国化学会色谱专业委员会主任、中国抗癌协会肿瘤代谢委员会副主任、中国化学会理事、中国质谱学会常务理事。2007-2014年曾任J. Chromatogr. Beditor, 现正在担任TrAC的特约编辑和Anal. Chim. Acta, Metabolomics, Anal. Bioanal. Chem.Metabolites, J. Pharm. Biomed. Anal.J. Chromatogr. B,和J. Sep. Sci.10多个国内外杂志编委。国际高效液相色谱会议(HPLC)科学委员会常委,第30届国际毛细管色谱会议和第3337届国际高效液相色谱会议副主席。他也是多届国际毛细管色谱会议(ISCC)的科学委员会委员和国际代谢组学会议的组织者和科学委员会成员。

至今为止,已发表SCI文章420多篇,包括PNAS, Nature Protocols, Hepatology, Clin. Chem., Cancer Res., Diabetes Care, Advanced science, Anal. Chem., TrAC, J. Chromatogr. A, J. Proteome Res.等国际著名杂志。H-指数: 59Web of Science)、74 (Google)。申请发明专利超百件(其中50多项已授权)。一项成果获国家科技进步二等奖(第五名),一项获辽宁省科技发明二等奖(第一名),两项成果获中国分析测试协会科学技术成果一等奖。

许国旺研究员一直从事色谱及其联用技术的基础理论及应用研究。根据样品对象的复杂性,在方法学上,走过了从经典一维色谱到中心切割多维色谱、再到全二维色谱的研究过程,逐渐形成了以“多维色谱+联用技术+化学信息学”的科研特色;在研究对象上,从石化、环保领域逐渐实现了向生命科学(药物、代谢组学、生物催化)领域的转化。从1996年开始开展“健康和代谢的关系”研究,并逐步进入代谢组学领域,将研究方向集中到代谢组学的技术平台和其在重大疾病的生物标志物发现、中药疗效毒性和作用机理研究等。许国旺是我国最早进行代谢组学研究的学者之一。

主要研究方向:复杂样品分离分析方法的创新性研究;代谢组学分析技术平台及其在疾病、中药、植物表型、食品安全等方面应用的研究。

 

代表性文章:

  1. Fujian Zheng, Xinjie Zhao, Zhongda Zeng, Lichao Wang, Wangjie Lv, Qingqing Wang, Guowang Xu* (2020) Development of plasma pseudotargeted metabolomics method based on ultra-high performance liquid chromatography-mass spectrometry, Nature Protocols, acceptedManuscript No.: NP-P190392C

  2. Di Yu, Yang Liu, Yiqiang Zhou, Guowang Xu, Chunzhang Yang (2020) Triptolide suppresses IDH1-mutated malignancy via Nrf2-driven glutathione metabolism, PNAS, https://www.pnas.org/content/early/2020/04/17/1913633117

  3. Zujiang Yu,*, Jingjing Li, Ranran Sun, Yang Zhou, Qi Zhang, Qiongye Wang, Guangying Cui, Juan Li, Zhenfeng Duan, Xiaochao Ma, Yuming Xu, Zhichao Wang, Peiyuan Yin, Hailong Piao, Jun Lv, Xiaorui Liu, Yanfang Wang, Ming Fang, Zhengping Zhuang*, Guowang Xu*, Quancheng Kan* (2020) Switching from Fatty Acid Oxidation to Glycolysis Improves the Outcome of Acute-On-Chronic Liver Failure, Advanced Science, 7, 1902996.

  4. Rui Wu, Zeming Wu, Xianhui Wang, Pengcheng Yang, Dan Yu, Chunxia Zhao, Guowang Xu*, Le Kang* (2012) Metabolomic analysis reveals that carnitines are key regulatory metabolites in phase transition of the locusts, PNAS, 109(9):3259-63

  5. Ping Luo#, Peiyuan Yin#, Rui Hua#, Yexiong Tan, Zaifang Li#, Gaokun Qiu, Zhenyu Yin, Xingwang Xie, Xiaomei Wang, Wenbin Chen, Lina Zhou, Xiaolin Wang, Yanli Li, Hongsong Chen, Ling Gao, Xin Lu, Tangchun Wu*, Hongyang Wang*, Junqi Niu*, Guowang Xu* (2018) A large-scale, multi-center serum metabolite biomarkers identification study for the early detection of hepatocellular carcinoma, Hepatology, 67:662-675

  6. Ling Tang, Jun Zeng, Pengyu Geng, Chengnan Fang, Yang Wang, Mingju Sun, Changsong Wang, Jiao Wang, Peiyuan Yin, Chunxiu Hu, Lei Guo, Jane J. Yu, Peng Gao, Enyou Li, Zhengping Zhuang, Guowang Xu* ,Yang Liu* (2018) Global metabolic profiling identifies a pivotal role of proline and hydroxyproline metabolism in supporting hypoxic response in hepatocellular carcinoma, Clin. Cancer Res., 24(2):474-485

  7. Di Yu, Lina Zhou, Qiuhui Xuan, Lichao Wang, Xinjie Zhao, Xin Lu, Guowang Xu* (2018) Strategy for Comprehensive Identification of Acylcarnitines Based on Liquid Chromatography—High-Resolution Mass Spectrometry, Anal. Chem., 90(9):5712-5718.

  8. Xinyu Liu, Miriam Hoene, Peiyuan Yin, Louise Fritsche, Peter Plomgaard, Jakob S. Hansen, Christos T. Nakas, Andreas M. Niess, Jens Hudemann, Michael Haap, Maimuna Mendy, Cora Weigert, Xiaolin Wang, Andreas Fritsche, Andreas Peter, Hans-Ulrich Häring, Guowang Xu*, Rainer Lehmann*(2018) Quality Control of Serum and Plasma by Quantification of (4E,14Z)-Sphingadienine-C18-1-Phosphate Uncovers Common Preanalytical Errors During Handling of Whole Blood, Clin. Chem., 64(5): 810–819

  9. Yaping Shao, Guozhu Ye, Shancheng Ren, Hai-long Piao, Xinjie Zhao, Xin Lu, Fubo Wang, Wang Ma, Jia Li, Peiyuan Yin, Tian Xia, Chuanliang Xu, Jane J. Yu, Yinghao Sun*, Guowang Xu* (2018) Metabolomics and transcriptomics profiles delineate the dysregulation of tricarboxylic acid cycle and related mechanism in prostate cancer, International Journal of Cancer, 143, 396–407.

  10. Shuangyuan Wang#, Zhichao Wang#, Lina Zhou, Xianzhe Shi*, Guowang Xu* (2017) Comprehensive analysis of short-, medium- and long-chain acyl-coenzyme As by on-line two dimensional liquid chromatography-mass spectrometry, Anal. Chem., 89(23):12902-12908

  11. Yanni Zhao, Zhiqiang Hao, Chunxia Zhao, Jieyu Zhao, Junjie Zhang, Yanli Li, Lili Li, Xin Huang, Xiaohui Lin, Xin Lu*, Guowang Xu*(2016) A Strategy for Large-Scale Metabolomics Study by Calibrating Random and Systematic Biases in Gas Chromatography-Mass Spectrometry, Anal. Chem. 88, 2234−2242

  12. Yanqing Fu, Zhihui Zhou, Hongwei Kong, Xin Lu, Xinjie Zhao, Yihui Chen, Jia Chen, Zeming Wu, Zhiliang Xu, Chunxia Zhao*, Guowang Xu* (2016) Non-targeted Screening Method for Illegal Additives based on Ultra Performance Liquid Chromatography-High Resolution Mass Spectrometry, Anal. Chem. 88, 8870−8877

  13. Hua Li, Qian Qin, Lizhen Qiao, Xianzhe Shi,* and Guowang Xu* (2015) Preparation of mesoporous SiO2@azobenzene-COOH chemoselective nanoprobes for comprehensive mapping of amino metabolites in human serum, Chem Commun (Camb), 51(56):11321-4.

  14. Ping Luo, Weidong Dai, Peiyuan Yin, Zhongda Zeng, Lina Zhou, Xiaolin Wang, Shili Chen, Xin Lu, Guowang Xu* (2015) Multiple Reaction Monitoring-Ion Pair Finder: A Systematic Approach To Transform Nontargeted Mode to Pseudotargeted Mode for Metabolomics Study Based on Liquid Chromatography–Mass Spectrometry, Anal. Chem., 87 (10): 5050–5055

  15. Yifei Zhang, Chunxiu Hu, Jie Hong, Jin Zeng, Ankang Lv, Qing Su, Yan Dong, Zhiguang Zhou, Weili Tang, Jiajun Zhao, Lianqun Cui, Dajin Zou, Dawang Wang, Hong Li, Chao Liu, Guoting Wu, Jie Shen, Dalong Zhu, Weiqing Wang, Weifeng Shen, Guang Ning*, Guowang Xu* (2014) Lipid profiling reveals different therapeutic effects of metformin and glipizide on patients with type 2 diabetes and coronary artery disease. Diabetes Care. 37(10): 2804-12.

  16. Weidong Dai, Peiyuan Yin, Zhongda Zeng, Hongwei Kong, Hongwei Tong, Zhiliang, Xu, Xin Lu, Rainer Lehmann*, Guowang Xu* (2014) Nontargeted modification-specific metabolomics study based on liquid chromatography-high-resolution mass spectrometry, Anal. Chem., 86(18): 9146-53

  17. Qiang Huang, Yexiong Tan, Peiyuan Yin, Lina Zhou, Guozhu Ye, Xin Lu, Hongyang Wang* and Guowang Xu* (2013) Metabolic characterization of hepatocellular carcinoma using non-targeted tissue metabolomics. Cancer Res. 73(16): 4992–5002.

  18. Jia Li, Miriam Hoene, Xinjie Zhao, Shili Chen, Hai Wei, Hans-Ulrich Häring, Xiaohui Lin, Zhongda Zeng, Cora Weigert, Rainer Lehmann*, Guowang Xu* (2013) Stable isotope-assisted lipidomics combined with non-targeted isotopomer filtering, a novel tool to unravel the complex dynamics of lipid metabolism, Anal. Chem.85(9):4651-7


  1.  

Prof. Dr. Guowang Xu graduated from department of chemical engineering of Zhejiang institute of engineering, China. In Sept., 1984 he became a graduate student in chromatography department of Dalian institute of chemical physics (DICP), Chinese Academy of Sciences, earned his Ph.D. degree in Jun., 1991. Subsequently, he joined the National chromatographic R. & A. center in DICP and was one head of the chromatographic groups since 1992 and an associate Professor since Jun.,1994. From Oct., 1995 to Sept.,1997, Prof. Xu was working at the Universitaet Medizinische Klinik in Tuebingen, Germany under a fellowship from Max-Planck-Institute. In Nov., 1997 he was promoted to professor and since May, 1999 a Ph.D. advisor at DICP. In 2004 he obtained the foundation for distinguished young scientists from National Natural Science Foundation of China. Since 2005 He has been the director of the metabonomics research center, the deputy director (2008-2016) and director (since 2017) of CAS Key Laboratory of Separation Science for Analytical Chemistry, and since 2016 the administrative vice-director of biotechnology division in DICP.

He is the president of Chromatography Committee of Chinese Society of Chemistry, trustee of the Chinese Society of Chemistry and deputy-president of the Tumor Metabolism Committee of Chinese Society of Anticancer, member of permanent scientific committee of HPLC conference since 2007. He was an editor of J. Chromatgor. B (2007-2014), and is also a contributing editor of TrAC and members of editorial board of the Anal. Chim. Acta, Metabolomics, Anal. Bioanal. Chem. , MetabolitesJ. Pharm. Biomed. Anal.J. Chromatogr. Band J. Sep. Sci. He was the co-Chairman of 30th ISCC in Dalian, China, 33rd HPLC in Kyoto, Japan and 37th HPLC in Dalian, China.

Prof. Xu has co-written 5 books and published more than 420 peer-reviewed papers in the ‘Web of Science Core Collection’ (WoS) indexed journals including PNAS, Nature Protocols, Hepatology, Clin. Chem., Cancer Res., Diabetes Care, Advanced Science, Anal. Chem., TrAC, J. Chromatogr. A, J. Proteome Res. (WoS H-index = 59, Google H-index =74) and holds more than 50 China patents.

His main research field is in the chromatography-related research and the metabolomics applications in disease biomarker discovery, traditional Chinese medicines and food safety.

 

Representative Publications

  1. Fujian Zheng, Xinjie Zhao, Zhongda Zeng, Lichao Wang, Wangjie Lv, Qingqing Wang, Guowang Xu* (2020) Development of plasma pseudotargeted metabolomics method based on ultra-high performance liquid chromatography-mass spectrometry, Nature Protocols, acceptedManuscript No.: NP-P190392C

  2. Di Yu, Yang Liu, Yiqiang Zhou, Guowang Xu, Chunzhang Yang (2020) Triptolide suppresses IDH1-mutated malignancy via Nrf2-driven glutathione metabolism, PNAS, https://www.pnas.org/content/early/2020/04/17/1913633117

  3. Zujiang Yu,*, Jingjing Li, Ranran Sun, Yang Zhou, Qi Zhang, Qiongye Wang, Guangying Cui, Juan Li, Zhenfeng Duan, Xiaochao Ma, Yuming Xu, Zhichao Wang, Peiyuan Yin, Hailong Piao, Jun Lv, Xiaorui Liu, Yanfang Wang, Ming Fang, Zhengping Zhuang*, Guowang Xu*, Quancheng Kan* (2020) Switching from Fatty Acid Oxidation to Glycolysis Improves the Outcome of Acute-On-Chronic Liver Failure, Advanced Science, 7, 1902996.

  4. Rui Wu, Zeming Wu, Xianhui Wang, Pengcheng Yang, Dan Yu, Chunxia Zhao, Guowang Xu*, Le Kang* (2012) Metabolomic analysis reveals that carnitines are key regulatory metabolites in phase transition of the locusts, PNAS, 109(9):3259-63

  5. Ping Luo#, Peiyuan Yin#, Rui Hua#, Yexiong Tan, Zaifang Li#, Gaokun Qiu, Zhenyu Yin, Xingwang Xie, Xiaomei Wang, Wenbin Chen, Lina Zhou, Xiaolin Wang, Yanli Li, Hongsong Chen, Ling Gao, Xin Lu, Tangchun Wu*, Hongyang Wang*, Junqi Niu*, Guowang Xu* (2018) A large-scale, multi-center serum metabolite biomarkers identification study for the early detection of hepatocellular carcinoma, Hepatology, 67:662-675

  6. Ling Tang, Jun Zeng, Pengyu Geng, Chengnan Fang, Yang Wang, Mingju Sun, Changsong Wang, Jiao Wang, Peiyuan Yin, Chunxiu Hu, Lei Guo, Jane J. Yu, Peng Gao, Enyou Li, Zhengping Zhuang, Guowang Xu* ,Yang Liu* (2018) Global metabolic profiling identifies a pivotal role of proline and hydroxyproline metabolism in supporting hypoxic response in hepatocellular carcinoma, Clin. Cancer Res., 24(2):474-485

  7. Di Yu, Lina Zhou, Qiuhui Xuan, Lichao Wang, Xinjie Zhao, Xin Lu, Guowang Xu* (2018) Strategy for Comprehensive Identification of Acylcarnitines Based on Liquid Chromatography—High-Resolution Mass Spectrometry, Anal. Chem., 90(9):5712-5718.

  8. Xinyu Liu, Miriam Hoene, Peiyuan Yin, Louise Fritsche, Peter Plomgaard, Jakob S. Hansen, Christos T. Nakas, Andreas M. Niess, Jens Hudemann, Michael Haap, Maimuna Mendy, Cora Weigert, Xiaolin Wang, Andreas Fritsche, Andreas Peter, Hans-Ulrich Häring, Guowang Xu*, Rainer Lehmann*(2018) Quality Control of Serum and Plasma by Quantification of (4E,14Z)-Sphingadienine-C18-1-Phosphate Uncovers Common Preanalytical Errors During Handling of Whole Blood, Clin. Chem., 64(5): 810–819

  9. Yaping Shao, Guozhu Ye, Shancheng Ren, Hai-long Piao, Xinjie Zhao, Xin Lu, Fubo Wang, Wang Ma, Jia Li, Peiyuan Yin, Tian Xia, Chuanliang Xu, Jane J. Yu, Yinghao Sun*, Guowang Xu* (2018) Metabolomics and transcriptomics profiles delineate the dysregulation of tricarboxylic acid cycle and related mechanism in prostate cancer, International Journal of Cancer, 143, 396–407.

  10. Shuangyuan Wang#, Zhichao Wang#, Lina Zhou, Xianzhe Shi*, Guowang Xu* (2017) Comprehensive analysis of short-, medium- and long-chain acyl-coenzyme As by on-line two dimensional liquid chromatography-mass spectrometry, Anal. Chem., 89(23):12902-12908

  11. Yanni Zhao, Zhiqiang Hao, Chunxia Zhao, Jieyu Zhao, Junjie Zhang, Yanli Li, Lili Li, Xin Huang, Xiaohui Lin, Xin Lu*, Guowang Xu*(2016) A Strategy for Large-Scale Metabolomics Study by Calibrating Random and Systematic Biases in Gas Chromatography-Mass Spectrometry, Anal. Chem. 88, 2234−2242

  12. Yanqing Fu, Zhihui Zhou, Hongwei Kong, Xin Lu, Xinjie Zhao, Yihui Chen, Jia Chen, Zeming Wu, Zhiliang Xu, Chunxia Zhao*, Guowang Xu* (2016) Non-targeted Screening Method for Illegal Additives based on Ultra Performance Liquid Chromatography-High Resolution Mass Spectrometry, Anal. Chem. 88, 8870−8877

  13. Hua Li, Qian Qin, Lizhen Qiao, Xianzhe Shi,* and Guowang Xu* (2015) Preparation of mesoporous SiO2@azobenzene-COOH chemoselective nanoprobes for comprehensive mapping of amino metabolites in human serum, Chem Commun (Camb), 51(56):11321-4.

  14. Ping Luo, Weidong Dai, Peiyuan Yin, Zhongda Zeng, Lina Zhou, Xiaolin Wang, Shili Chen, Xin Lu, Guowang Xu* (2015) Multiple Reaction Monitoring-Ion Pair Finder: A Systematic Approach To Transform Nontargeted Mode to Pseudotargeted Mode for Metabolomics Study Based on Liquid Chromatography–Mass Spectrometry, Anal. Chem., 87 (10): 5050–5055

  15. Yifei Zhang, Chunxiu Hu, Jie Hong, Jin Zeng, Ankang Lv, Qing Su, Yan Dong, Zhiguang Zhou, Weili Tang, Jiajun Zhao, Lianqun Cui, Dajin Zou, Dawang Wang, Hong Li, Chao Liu, Guoting Wu, Jie Shen, Dalong Zhu, Weiqing Wang, Weifeng Shen, Guang Ning*, Guowang Xu* (2014) Lipid profiling reveals different therapeutic effects of metformin and glipizide on patients with type 2 diabetes and coronary artery disease. Diabetes Care. 37(10): 2804-12.

  16. Weidong Dai, Peiyuan Yin, Zhongda Zeng, Hongwei Kong, Hongwei Tong, Zhiliang, Xu, Xin Lu, Rainer Lehmann*, Guowang Xu* (2014) Nontargeted modification-specific metabolomics study based on liquid chromatography-high-resolution mass spectrometry, Anal. Chem., 86(18): 9146-53

  17. Qiang Huang, Yexiong Tan, Peiyuan Yin, Lina Zhou, Guozhu Ye, Xin Lu, Hongyang Wang* and Guowang Xu* (2013) Metabolic characterization of hepatocellular carcinoma using non-targeted tissue metabolomics. Cancer Res. 73(16): 4992–5002.

  18. Jia Li, Miriam Hoene, Xinjie Zhao, Shili Chen, Hai Wei, Hans-Ulrich Häring, Xiaohui Lin, Zhongda Zeng, Cora Weigert, Rainer Lehmann*, Guowang Xu* (2013) Stable isotope-assisted lipidomics combined with non-targeted isotopomer filtering, a novel tool to unravel the complex dynamics of lipid metabolism, Anal. Chem.85(9):4651-7

 

Laboratory of High Resolution Separation/Analysis and Metabonomics   Dalian Institute of Chemical Physics, Chinese Academy of Sciences. All Rights Reserved.
中国科学院大连化学物理研究所  生物分子高分辨分离分析及代谢组学研究组(1808组)
地址: 大连市中山路457号, 邮编: 116023 电话: 0411-84379531; 传真: 0411-84379559     Email: g1808@dicp.ac.cn