Prof.Guowang Xu

作者:时间:2021-01-27点击数:

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Prof. Dr. Guowang Xu graduated from department of chemical engineering of Zhejiang institute of engineering, China. In Sept., 1984 he became a graduate student in chromatography department of Dalian institute of chemical physics (DICP), Chinese Academy of Sciences, earned his Ph.D. degree in Jun., 1991. Subsequently, he joined the National chromatographic R. & A. center in DICP and was one head of the chromatographic groups since 1992 and an associate Professor since Jun.,1994. From Oct., 1995 to Sept.,1997, Prof. Xu was working at the Universitaet Medizinische Klinik in Tuebingen, Germany under a fellowship from Max-Planck-Institute. In Nov., 1997 he was promoted to professor and since May, 1999 a Ph.D. advisor at DICP. In 2004 he obtained the foundation for distinguished young scientists from National Natural Science Foundation of China. Since 2005 he has been the director of the metabonomics research center, the deputy director (2008-2016) and director (since 2017) of CAS Key Laboratory of Separation Science for Analytical Chemistry,andsince 2016the administrative vice-director of biotechnology division in DICP.

He is the president of Chromatography Committee of Chinese Societyof Chemistry, trustee of the Chinese Societyof Chemistryand deputy-president of the Tumor Metabolism Committee of Chinese SocietyofAnticancer, member of permanent scientific committee of HPLC conference since 2007. He was an editor of J. Chromatgor. B (2007-2014), and is also a contributing editor of TrAC and members of editorial board of theAnal. Chem., Anal. Chim. Acta,J.Proteome Res., Metabolites,Metabolomics,Anal. Bioanal. Chem.,J. Chromatogr. B,J. Sep. Sci., JOAT, Bull Korean Chem. Soc., etc. He was the co-Chairman of 30th ISCC in Dalian, China, 33rd HPLC in Kyoto, Japan and 37th HPLC in Dalian, China.

Prof. Xu has co-written 5 books and published more than 400 peer-reviewed papers in the ‘Web of Science Core Collection’ (WoS) indexed journals including PNAS,Nature Protocols,Hepatology,Clin. Chem., Cancer Res., Diabetes Care, Advanced Science,Anal. Chem., TrAC,J. Chromatogr. A,J. Proteome Res.(WoS H-index = 62, Google H-index =76) and holds more than 50 China patents.

His main research field is in the chromatography-related research and the metabolomics applications in disease biomarker discovery, traditional Chinese medicines and food safety.

Representative Publications:

1.Fujian Zheng, Xinjie Zhao, Zhongda Zeng, Lichao Wang, Wangjie Lv, Qingqing Wang, Guowang Xu* (2020) Development of plasma pseudotargeted metabolomics method based on ultra-high performance liquid chromatography-mass spectrometry, Nature Protocols, 15(8):2519-2537

2.Di Yu, Yang Liu, Yiqiang Zhou, Guowang Xu, Chunzhang Yang (2020) Triptolide suppresses IDH1-mutated malignancy via Nrf2-driven glutathione metabolism, Proc Natl Acad Sci U S A. 117(18):9964-9972

3.Qiuhui Xuan#, Yang Ouyang#, Yanfeng Wang#, Liang Wu#, Huating Li, Yuanyuan Luo, Xinjie Zhao, Disheng Feng, Wangshu Qin, Chunxiu Hu, Lina Zhou, Xinyu Liu, Haidong Zou, Chun Cai, Jiarui Wu*, Weiping Jia*, Guowang Xu*(2020) Multiplatform Metabolomics Reveals Novel Serum Metabolite Biomarkers in Diabetic Retinopathy Subjects, 7, 2001714.

4.Zujiang Yu,*, Jingjing Li, Ranran Sun, Yang Zhou, Qi Zhang, Qiongye Wang, Guangying Cui, Juan Li, Zhenfeng Duan, Xiaochao Ma, Yuming Xu, Zhichao Wang, Peiyuan Yin, Hailong Piao, Jun Lv, Xiaorui Liu, Yanfang Wang, Ming Fang, Zhengping Zhuang*, Guowang Xu*, Quancheng Kan* (2020) Switching from Fatty Acid Oxidation to Glycolysis Improves the Outcome of Acute-On-Chronic Liver Failure, Advanced Science, 7, 1902996.

5.Rui Wu, Zeming Wu, Xianhui Wang, Pengcheng Yang, Dan Yu, Chunxia Zhao, Guowang Xu*, Le Kang* (2012) Metabolomic analysis reveals that carnitines are key regulatory metabolites in phase transition of the locusts, Proc Natl Acad Sci U S A, 109(9):3259-63

6.Ping Luo#, Peiyuan Yin#, Rui Hua#, Yexiong Tan, Zaifang Li#, Gaokun Qiu, Zhenyu Yin, Xingwang Xie, Xiaomei Wang, Wenbin Chen, Lina Zhou, Xiaolin Wang, Yanli Li, Hongsong Chen, Ling Gao, Xin Lu, Tangchun Wu*, Hongyang Wang*, Junqi Niu*, Guowang Xu* (2018) A large-scale, multi-center serum metabolite biomarkers identification study for the early detection of hepatocellular carcinoma, Hepatology, 67:662-675

7.Ling Tang, Jun Zeng, Pengyu Geng, Chengnan Fang, Yang Wang, Mingju Sun, Changsong Wang, Jiao Wang, Peiyuan Yin, Chunxiu Hu, Lei Guo, Jane J. Yu, Peng Gao, Enyou Li, Zhengping Zhuang, Guowang Xu* ,Yang Liu* (2018) Global metabolic profiling identifies a pivotal role of proline and hydroxyproline metabolism in supporting hypoxic response in hepatocellular carcinoma, Clin. Cancer Res., 24(2):474-485

8.Wangjie Lv, Lichao Wang, Qiuhui Xuan,Xinjie Zhao,Xinyu Liu,Xianzhe Shi *,Guowang Xu * (2020)PseudotargetedMethodbased on ParallelColumnTwo-DimensionalLiquidChromatography-Mass SpectrometryforBroadCoverage of Metabolomeand Lipidome, Anal. Chem., 92(8):6043-6050

9.Bohong Wang, Wangjie Lv, Mengmeng Chang, Chunxia Zhao,Xianzhe Shi*, Guowang Xu * (2020)UntargetedDefining Protein-Metabolites Interaction based onLabel-freeKinetic Size-Exclusion Chromatography-Mass Spectrometry, Anal. Chem. 92, 7657−7665.

10.Mengmeng Chang,Qingqing Wang,Wangshu Qin,Xianzhe Shi*, Guowang Xu*(2020) Rational Synthesis of Aptamer-Functionalized Polyethylenimine Modified Magnetic Graphene Oxide Composites for Highly Efficient Enrichment and Comprehensive Metabolomics Analysis of Exosomes, Anal. Chem. 92, 15497–15505

11.Xinyu Liu, Miriam Hoene, Peiyuan Yin, Louise Fritsche, Peter Plomgaard, Jakob S. Hansen, Christos T. Nakas, Andreas M. Niess, Jens Hudemann, Michael Haap, Maimuna Mendy, Cora Weigert, Xiaolin Wang, Andreas Fritsche, Andreas Peter, Hans-Ulrich Häring, Guowang Xu*, Rainer Lehmann*(2018) Quality Control of Serum and Plasma by Quantification of (4E,14Z)-Sphingadienine-C18-1-Phosphate Uncovers Common Preanalytical Errors During Handling of Whole Blood, Clin. Chem., 64(5): 810–819

12.Yaping Shao, Guozhu Ye, Shancheng Ren, Hai-long Piao, Xinjie Zhao, Xin Lu, Fubo Wang, Wang Ma, Jia Li, Peiyuan Yin, Tian Xia, Chuanliang Xu, Jane J. Yu, Yinghao Sun*, Guowang Xu* (2018) Metabolomics and transcriptomics profiles delineate the dysregulation of tricarboxylic acid cycle and related mechanism in prostate cancer, International Journal of Cancer, 143, 396–407.

13.Yanni Zhao, Zhiqiang Hao, Chunxia Zhao, Jieyu Zhao, Junjie Zhang, Yanli Li, Lili Li, Xin Huang, Xiaohui Lin, Xin Lu*, Guowang Xu*(2016) A Strategy for Large-Scale Metabolomics Study by Calibrating Random and Systematic Biases in Gas Chromatography-Mass Spectrometry, Anal. Chem. 88, 2234−2242

14.Yanqing Fu, Zhihui Zhou, Hongwei Kong, Xin Lu, Xinjie Zhao, Yihui Chen, Jia Chen, Zeming Wu, Zhiliang Xu, Chunxia Zhao*, Guowang Xu* (2016) Non-targeted Screening Method for Illegal Additives based on Ultra Performance Liquid Chromatography-High Resolution Mass Spectrometry, Anal. Chem. 88, 8870−8877

15.Hua Li, Qian Qin, Lizhen Qiao, Xianzhe Shi,* and Guowang Xu* (2015) Preparation of mesoporous SiO2@azobenzene-COOH chemoselective nanoprobes for comprehensive mapping of amino metabolites in human serum, Chem Commun (Camb), 51(56):11321-4.

16.Ping Luo, Weidong Dai, Peiyuan Yin, Zhongda Zeng, Lina Zhou, Xiaolin Wang, Shili Chen, Xin Lu, Guowang Xu* (2015) Multiple Reaction Monitoring-Ion Pair Finder: A Systematic Approach To Transform Nontargeted Mode to Pseudotargeted Mode for Metabolomics Study Based on Liquid Chromatography–Mass Spectrometry, Anal. Chem., 87 (10): 5050–5055

17.Yifei Zhang, Chunxiu Hu, Jie Hong, Jin Zeng, Ankang Lv, Qing Su, Yan Dong, Zhiguang Zhou, Weili Tang, Jiajun Zhao, Lianqun Cui, Dajin Zou, Dawang Wang, Hong Li, Chao Liu, Guoting Wu, Jie Shen, Dalong Zhu, Weiqing Wang, Weifeng Shen, Guang Ning*, Guowang Xu* (2014) Lipid profiling reveals different therapeutic effects of metformin and glipizide on patients with type 2 diabetes and coronary artery disease. Diabetes Care. 37(10): 2804-12.

18.Weidong Dai, Peiyuan Yin, Zhongda Zeng, Hongwei Kong, Hongwei Tong, Zhiliang, Xu, Xin Lu, Rainer Lehmann*, Guowang Xu* (2014) Nontargeted modification-specific metabolomics study based on liquid chromatography-high-resolution mass spectrometry, Anal. Chem., 86(18): 9146-53

19.Qiang Huang, Yexiong Tan, Peiyuan Yin, Lina Zhou, Guozhu Ye, Xin Lu, Hongyang Wang* and Guowang Xu* (2013) Metabolic characterization of hepatocellular carcinoma using non-targeted tissue metabolomics. Cancer Res. 73(16): 4992–5002.

20.Jia Li, Miriam Hoene, Xinjie Zhao, Shili Chen, Hai Wei, Hans-Ulrich Häring, Xiaohui Lin, Zhongda Zeng, Cora Weigert, Rainer Lehmann*, Guowang Xu* (2013) Stable isotope-assisted lipidomics combined with non-targeted isotopomer filtering, a novel tool to unravel the complex dynamics of lipid metabolism, Anal. Chem.85(9):4651-7

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Laboratory of High Resolution Separation/Analysis and Metabonomics   Dalian Institute of Chemical Physics, Chinese Academy of Sciences. All Rights Reserved.
中国科学院大连化学物理研究所  生物分子高分辨分离分析及代谢组学研究组(1808组)
地址: 大连市中山路457号, 邮编: 116023 电话: 0411-84379531; 传真: 0411-84379559     Email: g1808@dicp.ac.cn