Prof.Guowang Xu

作者:时间:2021-01-27点击数:

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Prof. Dr. Guowang Xu graduated from department of chemical engineering of Zhejiang institute of engineering, China. In Sept., 1984 he became a graduate student in chromatography department of Dalian institute of chemical physics (DICP), Chinese Academy of Sciences, earned his Ph.D. degree in Jun., 1991. Subsequently, he joined the National chromatographic R. & A. center in DICP and was one head of the chromatographic groups since 1992 and an associate Professor since Jun.,1994. From Oct., 1995 to Sept.,1997, Prof. Xu was working at the Universitaet Medizinische Klinik in Tuebingen, Germany under a fellowship from Max-Planck-Institute. In Nov., 1997 he was promoted to professor and since May, 1999 a Ph.D. advisor at DICP. In 2004 he obtained the foundation for distinguished young scientists from National Natural Science Foundation of China. Since 2005 He has been the director of the metabonomics research center, the deputy director (2008-2016) and director (since 2017) of CAS Key Laboratory of Separation Science for Analytical Chemistry, and since 2016 the administrative vice-director of biotechnology division in DICP.

He is the president of Chromatography Committee of Chinese Society of Chemistry, trustee of the Chinese Society of Chemistry and deputy-president of the Tumor Metabolism Committee of Chinese Society of Anticancer, member of permanent scientific committee of HPLC conference since 2007. He was an editor of J. Chromatgor. B (2007-2014), and is also a contributing editor of TrAC and members of the editorial board of more than 10 journals including Anal. Chem., Anal. Chim. ActaJ. Proteome Res., MetabolitesMetabolomicsAnal. Bioanal. Chem.J. Chromatogr. BJ. Sep. Sci., JOAT, Bull Korean Chem. Soc., etc. He was the co-Chairman of 30th ISCC in Dalian, China, 33rd HPLC in Kyoto, Japan and 37th HPLC in Dalian, China.

Prof. Xu has co-written 5 books and published more than 480 peer-reviewed papers in the ‘Web of Science Core Collection’ (WoS) indexed journals including PNAS, Nature Protocols, Hepatology, Clin. Chem., Cancer Res., Advanced Science, Diabetes Care, Anal. Chem., TrAC, J. Chromatogr. A, J. Proteome Res. and Nature Methods (WoS H-index = 67, Google H-index =83) and more than 70 China patents were authorized.

He has also received several awards including the second prize of national science and technology progress (2011), the second prize of Liaoning province science and technology invention (2011) and the grand prize of Science and Technology of China Association of Instrument Analysis (CAIA) (2020) etc.

His main research field is in the chromatography-related research and the metabolomics/exposomics applications in disease biomarker discovery, traditional Chinese medicines and food safety.


Representative Publications:

1. Saleh Alseekh*, Asaph Aharoni, Yariv Brotman, Kévin Contrepois, John D'Auria, Jan Ewald, Jennifer C Ewald , Paul D Fraser, Patrick Giavalisco, Robert D Hall , Matthias Heinemann , Hannes Link, Jie Luo, Steffen Neumann , Jens Nielsen, Leonardo Perez de Souza, Kazuki Saito, Uwe Sauer, Frank C Schroeder, Stefan Schuster, Gary Siuzdak, Aleksandra Skirycz, Lloyd W Sumner, Michael P Snyder, Huiru Tang , Takayuki Tohge, Yulan Wang, Weiwei Wen, Si Wu, Guowang Xu, Nicola Zamboni, Alisdair R. Fernie* (2021) Mass spectrometry-based metabolomics: a guide for annotation, quantification and best reporting practices, Nature Methods, 18(7):747-756.

2. Tianrun Xu, Hang Li, Disheng Feng, Xianzhe Shi, Chunxiu Hu*, Guowang Xu* (2021) Lipid profiling of 20 mammalian cells by capillary microsampling combined with high-resolution spectral stitching nanoelectrospray ionization direct-infusion mass spectrometry, Anal. Chem. 93, 10031−10038.

3. Lichao Wang, Wangjie Lv, Xiaoshan Sun, Fujian Zheng, Tianrun Xu, Xinyu Liu, Hang Li, Xin Lu, Xiaojun Peng, Chunxiu Hu*, Guowang Xu* (2021) A strategy for nontargeted metabolomics annotation and quantitation using a high-resolution spectral-stitching nanoelectrospray direct-infusion mass spectrometry with data independent acquisition, Anal. Chem. 2021, 93, 10528−10537.

4. Mengmeng Chang, Qingqing Wang, Xinyu Liu*, Xianzhe Shi*, Guowang Xu* (2021) Facile Synthesis of Antibody-Coupled Polydopamine Coated Magnetic Graphene Oxide Composites for Efficient Immunopurification and Metabolomics Analysis of Mitochondria, Anal. Chem., 93, 11099−11107.

5. Di Yu, Fujian Zheng, Lichao Wang, Chao Li, Xin Lu, Xiaohui Lin, Lina Zhou*, Guowang Xu* (2021) A Novel Stable Isotope-Resolved Metabolomics Method for Small Numbers of Cells by Using Chip-based Nano-electrospray Mass Spectrometry, Anal. Chem., 93, 13765−13773.

6. Fujian Zheng, Xinjie Zhao, Zhongda Zeng, Lichao Wang, Wangjie Lv, Qingqing Wang, Guowang Xu* (2020) Development of plasma pseudotargeted metabolomics method based on ultra-high performance liquid chromatography-mass spectrometry, Nature Protocols, 15(8):2519-2537.

7. Di Yu, Yang Liu, Yiqiang Zhou, Guowang Xu*, Chunzhang Yang* (2020) Triptolide suppresses IDH1-mutated malignancy via Nrf2-driven glutathione metabolism, Proc Natl Acad Sci U S A, 117(18):9964-9972.

8. Zujiang Yu,*, Jingjing Li, Ranran Sun, Yang Zhou, Qi Zhang, Qiongye Wang, Guangying Cui, Juan Li, Zhenfeng Duan, Xiaochao Ma, Yuming Xu, Zhichao Wang, Peiyuan Yin, Hailong Piao, Jun Lv, Xiaorui Liu, Yanfang Wang, Ming Fang, Zhengping Zhuang*, Guowang Xu*, Quancheng Kan* (2020) Switching from Fatty Acid Oxidation to Glycolysis Improves the Outcome of Acute-On-Chronic Liver Failure, Advanced Science, 7, 1902996.

9. Qiuhui Xuan#, Yang Ouyang#, Yanfeng Wang#, Liang Wu#, Huating Li, Yuanyuan Luo, Xinjie Zhao, Disheng Feng, Wangshu Qin, Chunxiu Hu, Lina Zhou, Xinyu Liu, Haidong Zou, Chun Cai, Jiarui Wu*, Weiping Jia*, Guowang Xu* (2020) Applications of Multi-Platform Metabolomics in Studying Metabolic Pathway Dysregulation and Discovering Novel Serum Metabolite Biomarkers to Identify Diabetic Retinopathy Subjects from Patients with Diabetes, Advanced Science, 2020, 7, 2001714.

10. Wangjie Lv, Lichao Wang, Qiuhui Xuan, Xinjie Zhao, Xinyu Liu, Xianzhe Shi *, Guowang Xu * (2020) Pseudotargeted Method based on Parallel Column Two-Dimensional Liquid Chromatography-Mass Spectrometry for Broad Coverage of Metabolome and Lipidome, Anal. Chem., 92(8):6043-6050.

11. Yifei Zhang, Yanyun Gu, Huahui Ren, Shujie Wang, Huanzi Zhong, Xinjie Zhao,Jing Ma, Xuejiang Gu, Yaoming Xue, Shan Huang, Jialin Yang, Li Chen, Gang Chen, Shen Qu, Jun Liang, Li Qin, Qin Huang, Yongde Peng, Qi Li, Xiaolin Wang, Kong Ping, Guixue Hou, Mengyu Gao, Zhun Shi, Xuelin Li, Yixuan Qiu, Yuanqiang Zou, Huanming Yang, Jian Wang, Guowang Xu, Shenghan Lai, Junhua Li*, Guang Ning*,Weiqing Wang* (2020) Gut microbiome-related effects of berberine and probiotics on type 2 diabetes (the PREMOTE study), Nature Communications, 11(1): 5015.

12. Wangjie Lv #, Xianzhe Shi #, Shuangyuan Wang, Guowang Xu *(2019) Multidimensional liquid chromatography-mass spectrometry for metabolomics and lipidomics, TrAC-Trend Anal. Chem., 120, 115302 .

13. Xinyu Liu#, Lina Zhou#, Xianzhe Shi, Guowang Xu* (2019) New advances in analytical methods for mass spectrometry-based large-scale metabolomics study, TrAC-Trend Anal. Chem., 121, 115665.

14. Ping Luo#, Peiyuan Yin#, Rui Hua#, Yexiong Tan, Zaifang Li#, Gaokun Qiu, Zhenyu Yin, Xingwang Xie, Xiaomei Wang, Wenbin Chen, Lina Zhou, Xiaolin Wang, Yanli Li, Hongsong Chen, Ling Gao, Xin Lu, Tangchun Wu*, Hongyang Wang*, Junqi Niu*, Guowang Xu* (2018) A large-scale, multi-center serum metabolite biomarkers identification study for the early detection of hepatocellular carcinoma, Hepatology, 67:662-675.

15. Ling Tang, Jun Zeng, Pengyu Geng, Chengnan Fang, Yang Wang, Mingju Sun, Changsong Wang, Jiao Wang, Peiyuan Yin, Chunxiu Hu, Lei Guo, Jane J. Yu, Peng Gao, Enyou Li, Zhengping Zhuang, Guowang Xu* ,Yang Liu* (2018) Global metabolic profiling identifies a pivotal role of proline and hydroxyproline metabolism in supporting hypoxic response in hepatocellular carcinoma, Clin. Cancer Res., 24(2):474-485.

16. Di Yu, Lina Zhou, Qiuhui Xuan, Lichao Wang, Xinjie Zhao, Xin Lu, Guowang Xu* (2018) Strategy for Comprehensive Identification of Acylcarnitines Based on Liquid Chromatography—High-Resolution Mass Spectrometry, Anal. Chem., 90(9):5712-5718.

17. Xinyu Liu, Miriam Hoene, Peiyuan Yin, Louise Fritsche, Peter Plomgaard, Jakob S. Hansen, Christos T. Nakas, Andreas M. Niess, Jens Hudemann, Michael Haap, Maimuna Mendy, Cora Weigert, Xiaolin Wang, Andreas Fritsche, Andreas Peter, Hans-Ulrich Häring, Guowang Xu*, Rainer Lehmann*(2018) Quality Control of Serum and Plasma by Quantification of (4E,14Z)-Sphingadienine-C18-1-Phosphate Uncovers Common Preanalytical Errors During Handling of Whole Blood, Clin. Chem., 64(5): 810–819.

18. Yaping Shao, Guozhu Ye, Shancheng Ren, Hai-long Piao, Xinjie Zhao, Xin Lu, Fubo Wang, Wang Ma, Jia Li, Peiyuan Yin, Tian Xia, Chuanliang Xu, Jane J. Yu, Yinghao Sun*, Guowang Xu* (2018) Metabolomics and transcriptomics profiles delineate the dysregulation of tricarboxylic acid cycle and related mechanism in prostate cancer, International Journal of Cancer, 143, 396–407.

19. Shuangyuan Wang#, Zhichao Wang#, Lina Zhou, Xianzhe Shi*, Guowang Xu* (2017) Comprehensive analysis of short-, medium- and long-chain acyl-coenzyme As by on-line two dimensional liquid chromatography-mass spectrometry, Anal. Chem., 89(23):12902-12908.

20. Rui Wu, Zeming Wu, Xianhui Wang, Pengcheng Yang, Dan Yu, Chunxia Zhao, Guowang Xu*, Le Kang* (2012) Metabolomic analysis reveals that carnitines are key regulatory metabolites in phase transition of the locusts, Proc Natl Acad Sci U S A, 109(9):3259-63.

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Laboratory of High Resolution Separation/Analysis and Metabonomics   Dalian Institute of Chemical Physics, Chinese Academy of Sciences. All Rights Reserved.
中国科学院大连化学物理研究所  生物分子高分辨分离分析及代谢组学研究组(1808组)
地址: 大连市中山路457号, 邮编: 116023 电话: 0411-84379531; 传真: 0411-84379559     Email: g1808@dicp.ac.cn